Question

____________and ____________are chromosomal mutations that may activate cellular oncogenes by moving them to new regulatory sequences where they become over-expressed.(a) Duplications; deletions(b) Inversions; translocations(c) Duplications; inversions(d) Deletions; translocations(e) Aneuploidy; deletions

Answer 1

Answer:

(d) Deletions; translocations

Explanation:

Deletion mutations: It is the removal of a number of nucleotides from a DNA sequence.  Deletions that result in frameshifts, that is, disrupt the 3-nucleotide reading frame can cause changes in regulatory sequences inducing over-expression of certain genes.

Translocation mutations: Are caused the the rearrangement of genes in chromosomes that are usually in close proximity. Encountering new enhancers and/or promoters can cause oncogene activation.