The dot product between two vectors is defined as
[tex]v_1\cdot v_2 = ||v_1||\cdot ||v_2||\cdot \cos(\alpha)[/tex]
where [tex]\alpha[/tex] is the angle between the two vectors.
So, we deduce
[tex]\cos(\alpha) = \dfrac{v_1\cdot v_2}{||v_1||\cdot ||v_2||}[/tex]
The dot product is computed as the sum of the product of correspondent coordinates:
[tex](2,5)\cdot(4,-3) = 2\cdot 4 + 5\cdot(-3) = 8-15 = -7[/tex]
whereas the norm of a vector is the square root of the sum of the squares of the coordinates:
[tex]||v_1|| = \sqrt{2^2+5^2}=\sqrt{29},\quad ||v_1|| = \sqrt{4^2+(-3)^2}=5[/tex]
So, we have
[tex]\cos(\alpha) = \dfrac{-7}{5\sqrt{29}} = -0.26[/tex]
This implies
[tex]\alpha = \arccos(-0.26) \approx 105[/tex]