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Native Americans were also at risk during the colonial era because they had no immunity to diseases brought over from Europe, such as smallpox, unlike some Europeans who had.
The diseases that European explorers and colonists brought to America with them were not immune to the native peoples of that continent. American Indians died from illnesses like smallpox, influenza, measles, and even chicken pox. While Indians lacked any immunity to these illnesses, Europeans were accustomed to them. Smallpox, measles, typhoid, and cholera spread swiftly and drastically reduced Native American populations. Because Native Americans were not immune to these illnesses, the disease spread fast among them. Up to 95% of the indigenous people in the Americas perished as a result. During the colonial era, Native Americans resisted European attempts to take over more land and exert more control over them, but they found it difficult to do so due to a variety of issues, such as new diseases, the slave trade, and an ever-increasing European population.
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