Question

The LD 50 for a drug is the dose that would be lethal for
50% of the population. LD50 for aspirin in rats is 1.75
grams per kilogram of body weight. Calculate the
number of tablets containing 325 mg of aspirin a 70-kg
human would have to consume to achieve this dose?

Answer 1

The number of tablets containing 325 mg of aspirin a 70-kg human would have to consume to achieve this dose is 4

To reach the LD50 dose, one must give (LD50 times the weight of the rat) grams of aspirin:

m=1.75 (g·kg^(-1))·7 (g)=12.25(g)

Then, we can calculate the number of aspirin tablets that contain 12.25 g of aspirin:

N=(12.250(g))/(325 (mg))=3981.2 ≈4

• Aspirin is also referred to as acetylsalicylic acid and is used as a medication used to reduce pain, fever, and/or inflammation.
• Aspirin is a common drug for relieving minor aches, pains, and fevers.
• Aspirin is prepared by chemical synthesis from salicylic acid, through acetylation with acetic anhydride.

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