The term "occurs when a part of chromosome breaks off and is placed in the middle another chromosome" describes the process of insertion.
What is mutation?
- The alteration of gene sequence that cause a change in gene behavior is called as mutation.
- The sequence of DNA in chromosomes can be altered in a number of ways including substitution, deletion, duplication, insertion, and inversion.
What is insertion?
- The insertion is a process of mutation which changes the sequence of DNA by adding nucleotides to the gene sequence.
- As the result of insertion, the activity of genes can be altered, or the derived protein won't function in a proper manner.
- The segment of DNA added may be small like a single base but can bring out significant variation in size.
- Interchromosomal insertion is the insertion of a segment of the chromosome into an interstitial region of a non-homologous chromosome.
- Intrachromosomal insertion is the translocation of a chromosome segment into a different region of the same chromosome.
- The effects of insertion vary depending on the size, gene content, and orientation of the inserted fragments.
- An example of insertion mutation is fragile X syndrome.
- In this mutation, 200 CGG nucleotide repeats are inserted into the gene segment and made it non-functional.
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