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The immune system not only fights pathogens; it also fights foreign cells, such as those introduced during tissue transplantation. this type of immune reaction is called Graft rejection or transplant rejection .
The immune system of the person who gets an organ after transplant surgery may alert them to the foreign nature of the organ. This occurs when the immune system of the patient notices that the antigens on the organ's cells are "mismatched."
Blood transfusion reactions or transplant rejection can be caused by mismatched or imperfectly matched organs. Doctors match the organ recipient and donor in order to lessen the likelihood of this reaction.
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The immune system not only fights pathogens; it also fights foreign cells, such as those introduced during tissue transplantation. This type of immune reaction is called Transplant or Graft rejection.
Rejection occurs when the recipient’s immune system recognizes the donor tissue as foreign or non-self, thereby, triggering an immune response. The major histocompatibility complex markers MHC I and MHC II which are more specifically known as Human Leukocyte Antigens (HLAs), play an important role in transplant rejection.
The immune response linked with a transplanted organ consists of both cellular (lymphocyte mediated) and humoral (antibody mediated) mechanisms. Although other cell types are also involved, the T cells are central in the rejection of grafts.
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