To open a folder on the desktop using a mouse, you should place the pointer of the mouse over the target object and double click , in rapid succession, using the left mouse button.
When a person is known to be using Windows 10 or an older version of any given Windows, a person can be able to open files and folders through the act of double-clicking on them.
Note that based on the above, if a person can alter this behavior to open files using a single click ( that is the mouse is used by double-clicking on a single click).
Therefore, based on the above, To open a folder on the desktop using a mouse, you should place the pointer of the mouse over the target object and double click , in rapid succession, using the left mouse button.
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