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During the relaxation period, Ca2 is re-sequestered into the sarcoplasmic reticulum by Ca2+ AtPAse.
- During relaxation, Ca2+ is actively transported by the Ca2+ ATPase, from the cytosol into the sarcoplasmic reticulum.
- Each time we move a muscle, trillions of myosin motors work together to make that movement possible. Calcium ions are used by our muscle cells to coordinate this significant molecular effort.
- Muscles can unwind using the calcium pump following this frantic burst of calcium-induced contraction.
- The sarcoplasmic reticulum's membrane contains the pump. Sometimes it is so abundant that it may account for 90% of the protein there.
- By returning calcium ions to the sarcoplasmic reticulum with the help of ATP, the muscle is able to relax by lowering the calcium concentration surrounding the actin and myosin filaments.
- Similar pumps can be found in the cell membrane of the majority of cells, and calcium ions are also used for signaling inside other cells.
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Ca2 is re-sequestered into the sarcoplasmic reticulum during the relaxation period by Ca2+ ATPase.
What do you mean by sarcoplasmic reticulum?
Similar to the smooth endoplasmic reticulum in other cells, the sarcoplasmic reticulum (SR) is a membrane-bound structure found in muscle cells. The SR's primary job is to hold calcium ions (Ca2+). The concentration of calcium ions within a cell is 10,000 times lower than the concentration of calcium ions outside the cell, ensuring that calcium ion levels are kept relatively constant.
Fish cardiomyocytes have various types of sarcoplasmic reticulum (SR):
- junctional SR(jSR).
- free SR (fSR)
The sarcolemmal network or the t-tubular network is peripherally coupled with jSR paperwork. Rows of proteins referred to as "feet" are seen between the 2 membranes in peripheral connections where the jSR profile coincides with the sarcolemma or t-tubule. These proteins function as ryanodine receptor channels that are launched by Ca2+. Because fSR is not closely connected to any other membrane system, it may be found anywhere in the cardiomyocyte.
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