Question

Ras, like many small G-proteins, hydrolyzes GTP slowly on its own, but its enzymatic activity is increased significantly in the presence of GTPase activating proteins (GAPs), which act during growth factor signal transduction. Imagine you discovered a novel mutation in one of these GAPs that cannot bind to ras. This mutation would have the effect of___________. a. Increasing cAMP production b. Increasing Protein Kinase A activityc. Increasing glucose productiond. Increasing cell proliferation.e. All of the above

Answer 1

Answer:

Correct option is D

Ras, like many small G-proteins, hydrolyzes GTP slowly on its own, but its enzymatic activity is increased significantly in the presence of GTPase activating proteins (GAPs), which act during growth factor signal transduction. Imagine you discovered a novel mutation in one of these GAPs that cannot bind to ras. This mutation would have the effect of increasing cell proliferation.

Explanation:

Without GAPs, ras will lead to unregulated cell proliferation.