The five classic signs of localized inflammation are redness, warmth, pain, swelling, and altered function at the affected site. Altered function is caused when swelling interferes with the movement and function of the inflamed area. The other signs are matched with their causes below. Which sign and cause are mismatched?
Choose one:A. pain – increased production of prostaglandinB. warmth – increased production of pyrogensC. redness – increased blood flow to the siteD. swelling – increased vascular permeability

During the inflammatory response, the release of histamine by mast cells at the site of injury or pathogenic infection occurs. Histamine is a vasodilator and widens the blood vessels to increase the blood flow towards the affected site. The resultant increased blood supply to the affected site produces warmth. Histamine also makes the capillaries at the inflammation site more permeable to allow leakage of tissue fluid resulting in swelling due to buildup of tissue fluid.