Histone acetyltransferases (HATs) are capable of remodeling chromatin by adding acetyl groups to various lysine residues in histones that comprise the nucleosome. Following this modification, the lysine residue no longer has a positive charge. Which statement is true?
-Histones in general have a net negative charge that allow them to bind to DNA. Acetylation of histones, decreases their positive charge and strengthens the histone--DNA interaction
-Histones in general have a net negative charge that allow them to bind to DNA. Acetylation of histones, decreases their positive charge and weakens the histone-DNA interaction.
-Histones in general have a net positive charge that allow them to bind to DNA. Acetylation of histones, decreases their positive charge and weakens the histone-DNA interaction.
-Histones in general have a net positive charge that allow them to bind to DNA. Acetylation of histones, decreases their positive charge and strengthens the histone-DNA interaction.

The correct answer is "Histones in general have a net negative charge that allow them to bind to DNA. Acetylation of histones, decreases their positive charge and weakens the histone-DNA interaction".

Explanation:

Histone acetyltransferases (HATs) are regulators of gene activation and deactivation, achieved by the transference of an acetyl group from acetyl-CoA to histones. HATs function by the premise that histones in general have a net negative charge that allow them to bind to DNA. Acetylation of histones, decreases their positive charge and weakens the histone-DNA interaction. Therefore, most of the times histone acetylation increases gene expression, because the acetylated gene is free from the histones and is able to be encoded.