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Answer: The mitotic spindle is formed of microtubules. Microtubules are polymers of the protein tubulin; therefore, it is the mitotic spindle that is disrupted by these drugs. Without a functional mitotic spindle, the chromosomes will not be sorted or separated during mitosis. The cell will arrest in mitosis.
Explanation: The mitotic spindle is the macromolecular machine that segregates chromosomes to two daughter cells during mitosis. The major structural elements of the spindle are microtubule polymers, whose intrinsic polarity and dynamic qualities are very important for bipolar spindle organization and function.
The mitotic structure that is targeted by these drugs is the mitotic spindle and this leads to an uneven process of mitosis.
The process of nuclear cell division where the parent cells divide into two daughter cells in eukaryotic cells is known as mitosis.
It should be noted that there are protein structures that are called mitotic fibers that are formed during cell division. Chemotherapy drugs such as vincristine and colchicine disrupt the mitotic spindle.
When the mitotic spindle is disturbed, this then leads to an uneven process of mitosis. This leads to irregularities in the aligning, and attachment of chromosomes.
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