Suppose one parent is heterozygous for a dominant disorder and the other parent is homozygous normal. Draw a pedigree showing these parents and three possible offspring.

A pedigree represents the parental generation and the following ones, F1, F2, etcetera. In the exposed example there is an affected heter0zyg0us father, a normal recessive mother, two affected children and one healthy son.

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Available data:

one parent is heter0zyg0us for a dominant disorder
the other parent is h0m0zyg0us normal

Let us say that

M is the dominant allele that codes for the dissorder

m is the recessive allele that codes for normal phenotype

MM and Mm genotypes express the disorder

mm genotype expresses normal phenotype

We can first make the cross for you to picture it better,

Cross: heter0zyg0us with h0m0zyg0us recessive

Parentals) Mm x mm

Gametes) M m m m

Punnett square) M m

m Mm mm

F1)

1/2 = 50% of the progeny is expected to have the disorder, being either boys or girls

1/2 = 50% of the progeny is expected to be normal, being either boys or girls.

Now that we know the possible phenotypes of the progeny, let us make the pedigree.

When drawing a pedigree, you need to consider that:

Circles represent women

Squares represent men

Black symbols represent affected people

Empty symbols represent normal people

Roman numbers represent generations (parentals, F1, F2...)

Each individual can be represented by their names, letters, or numbers

So in the pedigree you will see,

First generation ⇒ I

Father ⇒ black square ⇒ Mm
Mother ⇒ empty circle ⇒ mm

Second generation ⇒ II

Son 1 ⇒ Black square ⇒ Mm
Daughter ⇒ Black circle ⇒ Mm
Son 2 Empty square mm

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