Decreased in plasma colloid oncotic pressure.
Hypoalbuminemia's low colloid oncotic pressure encourages water to flow from the intravascular to the interstitial region. Under normal circumstances, the growth and multiplication of lymphatics that boost lymphatic flow and the decrease in interstitial oncotic pressure brought on by the buildup of protein-free fluid both prevent the development of edema.
Additionally, the reduced transcapillary pressure gradient caused by the higher hydraulic pressure in the interstitium due to fluid buildup reduces the transudation of plasma fluid into the interstitial space. There isn't any conclusive proof that these typical defenses against edema production are altered in nephrotic individuals, though.
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