We can set it up like this:
[tex] \frac{192}{4} = \frac{2220}{x} [/tex]
This states that Sam can drive 192 miles in 4 hours and 2220 miles in x hours. To solve, we can use cross-multiplication:
[tex]192x = 2220*4 \\ 192x = 8880 \\ x = \frac{8880}{192} \\ x = 46.25[/tex]
It will take Sam 46.25 hours to drive the whole trip, or 46 hours and 15 minutes.