Answer:
The most appropriate answer would be option A.
The chromosome is a condensed form of the DNA in which DNA is tightly packed with the help of associated proteins.
For transcription to occur the DNA must unfold to expose sites for binding of different factors and enzymes such as helicase, RNA polymerase, clamp loader, transcription factors et cetera.
Thus, by folding the DNA into the chromosome, it regulates or decreases the transcription.
