A bone marrow transplant includes several steps. Order these steps for a successful transplant to cure leukemia.

A. donor match located

B. a sample of donor bone marrow containing healthy stem cells is introduced into the patient's bloodstream

C. patient's existing bone marrow and abnormal leukocytes are killed using a combination of chemotherapy and radiation

D. donor stem cells will migrate to patient's bone marrow and begin producing healthy leukocytes

Bone marrow transplant involves infusion of healthy HSCs (hematopoetic stem cells) to recipient from donor's blood to treat life-threatening conditions.

In patients, affected with leukemia, chemotherapy is done with or without radiation to kill unhealthy, cancerous cells.

To replace these damaged cells, a donor is matched that can donate his bone marrow cells to the patient.

Once the donor is found, a sample from his bone marrow is transplanted to the bloodstream of patient, from where these cells migrate to his bone marrow and make new healthy blood cells.

Thus, the correct order is C-A-B-D.