The best answer is c - temperature and pH can affect how enzymes work.
Enzymes are active only within a narrow pH range. The most favorable pH , the point where the enzyme is most active is called the optimum pH. Extremely high or low pH outside the optimum generally results in complete loss of activity for most enzymes.
Enzymes are also most active at a specific temperature called optimum temperature.
Temperatures significantly below the optimum slow down enzyme activity while those significantly above the optimum may denature the enzyme, causing permanent and irreversible damage.