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The first apparition warns Macbeth that he should watch out for Macduff.  His were allayed when the witches told him that he can be killed by a man not born of woman.  Later as Macbeth becomes, he kills all those who he suspects will be a threat to him.  Macduff escapes to England, Macbeths seizes his castles has everyone including Macduff’s wife and son killed.  Later Macduff vows to avenge their deaths and together with Prince Malcolm, attack Macbeth and defeat is army.  Macbeth is killed by Macduff who was born through Caesarian section not through natural means.   
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