Respuesta :
MAD protein are mutants cells and they can be refers to as mitotic arrest deficient. MAD protein act by recruiting the anaphase inhibitor MAD2 to dissociate kinetochores and its essentials from MAD2-CDC20 complex formation in vivo.
However, there mutation will produce defective protein and checkpoint failure by resulting into aneuploidy. Aneuploidy is when a cell finishes the process of mitosis and produces daughter cells with few or too many chromosomes and aneuploidy causes more than 90% of human cancer.
The potential outcome of a mutated MAD protein is development of aneuploidy in daughter cell.
Further Explanation:
The cell cycle is referred as the prearranged flow of steps that include the cellular division as well as cell growth. This cycle form two new daughter cells. The cycle is begins with the interphase. In this phase, mainly the cell replicates and matures its DNA.
The second stage of a cell cycle is the mitosis or M phase. Mitosis is a kind of cell division. In this, parental cells divide into two daughter cells which have the same number of chromosomes as that of the parent cell
MAD protein is a kind of a protein that mainly present in humans and this protein is encoded by MXD1 gene. This protein is mutant cell that is referred as mitotic arrest deficient. This protein has a role in recruiting an inhibitor MAD-2 which is anaphase inhibiter help in dissociating the kinetochores.
Development of any Mutations in the MAD protein can develop a defective protein and malfunction of the checkpoints. The cell ends the cell cycle by the last stage which mitosis. In the presence of mutated MAD protein daughter cell cannot develop properly. Daughter cell can have very low or high number of chromosome and can result in aneuploidy condition. Mainly aneuploidy cell develop or result in cancer cell.
Learn more:
1. Learn more about mitosis https://brainly.com/question/6462270
2. Learn more about the menstrual cycle https://brainly.com/question/723944
3. Learn more about meiosis https://brainly.com/question/94813
Answer Details:
Grade: High School
Subject: Biology
Chapter: Cell Cycle
Keywords:
Cell cycle, parent cell, mitosis, aneuploidy, daughter cell, protein, MAD, mutated protein, encoded, human, checkpoints, cancer cell, daughter cell, chromosome.
