Answer: Option (4) is the correct answer.
Explanation:
In a nuclear power plant, nuclear fission and fusion reactions occur.
During these reaction a large amount of heat is releases along with the release of radioisotopes. These radioisotopes have long half-lives as a result these emit harmful radiations which can either cause burns or blindness to the people around the nuclear power plant etc.
For example, isotope of Uranium-238 have longer half life.
Thus, we can conclude that a serious risk factor associated with the operation of a nuclear power plant is the production of radioisotopes with long half-lives.