32 mph
First, let's calculate the location of the particle at t=1, and t=4
t=1
s = 6*t^2 + 2*t
s = 6*1^2 + 2*1
s = 6 + 2
s = 8
t = 4
s = 6*t^2 + 2*t
s = 6*4^2 + 2*4
s = 6*16 + 8
s = 96 + 8
s = 104
So the particle moved from 8 to 104 over the time period of 1 to 4 hours. And the average velocity is simply the distance moved over the time spent. So:
avg_vel = (104-8)/(4-1) = 96/3 = 32
And since the units were miles and hours, that means that the average speed of the particle over the interval [1,4] was 32 miles/hour, or 32 mph.