1. Hybridization is a method of sexual reproduction whereas cloning is a method of asexual reproduction.
2. Hybrid animals are sterile, but cloned animals are fertile.
3. Hybrid organisms contain DNA from both male and female parents but cloned organisms contain DNA from only one type of parent.
4. Hybrid has superior character over its parents (improved hybrid vigor) but clones are 100% identical to their parent.
5. Hybridization gives only one hybrid progeny, whereas through cloning unlimited identical organisms can be produced.