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The main way in which John Marshall's interpretation of the constitution was different from Thomas Jefferson's is that Marshall believed that the Constitution could be interpreted fairly widely, while Jefferson was an "originalist". 

The correct answer is Marshall believed the Constitution granted strong federal powers; Jefferson did not.

Marshall’s interpretation of the Constitution was different from that of Tomas Jefferson’s in that is Marshall believed the Constitution granted strong federal powers; Jefferson did not.

John Marshall was a federalist. Jefferson was not. He was an anti-federalist. Then, John Marshall considered the idea of a strong central government. On the other side, Jefferson thought that a strong government was not the best option for a new nation and even worse, a strong federal government could turn into a tyranny.  


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