C4H10 (g) + (6.5) O2 (g) --> 4CO2 (g) + 5H2O (g)
Smallest coefficient of C4H10 is 1.
First, balance out the Carbon and Hydrogen atoms as they are limiting.
Second, calculate the number of Oxygen atoms and minus away those found in C4H10.
Divide the number with 2 as oxygen exists as O2. [It is OK to put a fraction in front of the molecule as long as there is 1 atom used in the reaction. ]