Hey there!
The reason why Roanoke became the "lost colony" was when the first time they got there they realized that they didn't have enough supplies so they went back to England leaving just a group of people behind, but when they got back they realized they were gone. They don't know why!
There are a lot of predictions on what happened to them, But I think they probably found another land and lived there instead. But you might have another reason!
Hope this helps!