Question

What is the cause of the hyperpigmentation seen in people with cushing syndrome?
a. permissive effects of aldosterone when cortisol levels are altered
b. hypersensitivity of melanocytes with sun exposure
c. elevated levels of acth
d. abnormal levels of cortisol?

Answer 1

c. Elevated levels of ACTH

Rationale: Bronze or brownish hyperpigmentation of the skin, mucous membranes, and hair occurs when there are very high levels of ACTH.