Absolute contraindications to warfarin include:
large esophageal varices
within 72 hours of major surgery
a platelet count less than 50 x 109/cu.mm which constitutes significant thrombocytopenia
hypersensitivity to the drug, such as skin ischemic necrosis or priapism
clinically significant bleeding condition – reassess risks after three months
pregnancy and within 48 hours of delivery because of its known teratogenicity, as well as its capacity to induce spontaneous abortion and fetal/perinatal bleeding
coagulation defects at baseline such that the INR is over 1.5
decompensated liver disease
