Answer:
The limitations of biomarkers for cervical intraepithelial neoplasia (CIN), microsatellite instability (MSI), and CpG island methylator phenotype (CIMP) vary. For CIN, challenges include sensitivity and specificity issues, as discussed in studies like "Performance of p16/Ki-67 immunostaining for detecting high-grade cervical intraepithelial neoplasia in cervical biopsies: a systematic review and meta-analysis."
In MSI, limitations involve the diversity of markers and interpretation challenges, as highlighted in research such as "Assessment of microsatellite instability in colorectal carcinoma using an in-house panel of markers: A single-institution experience."
For CIMP, limitations include heterogeneity in defining and detecting CIMP-positive tumors, as addressed in papers like "CpG island methylator phenotype in colorectal cancer: a prognostic factor or not?
