Which european powers dominated the great lakes region and mississippi river valley through most of the 18th century?

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Answer:  The correct answer is :  French colonies

Explanation:  France explored and claimed an extensive area called New France that included the mouth of the San Lorenzo River, the Great Lakes, the Mississippi River Delta, the Ohio Valley territory. It was the main French colony, which began with the exploration of the San Lorenzo river made by Jacques Cartier.

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