A 28-year-old woman, G3, P2, is in the third trimester of a previously uncomplicated pregnancy when she develops increasing lethargy with nausea, vomiting, and jaundice over a 10-day period. On physical examination, she has generalized jaundice and scattered ecchymoses over the trunk and extremities. The estimated fetal age is 35 weeks. Laboratory studies show total serum bilirubin of 5.8 mg/dL, AST of 122 U/L, ALT of 131 U/L, and alkaline phosphatase of 125 U/L. Which of the following histologic features is most likely to be found in a liver biopsy specimen?
□ (A) Concentric bile duct fibrosis
□ (B) Periportal PAS-positive hepatic globules
□ (C) Marked microvesicular steatosis
□ (D) Extensive intrahepatic hemosiderin deposition
□ (E) Inflammation with loss of intrahepatic bile ducts
□ (F) Multinucleated giant cells
