During the 1st part of the 1800's the North and the South grew in different ways. In the North, cities are where you can find wealth and manufacturing. There were a lot of skilled workers in the North. Meanwhile in the South, there was not much industrial manufacturing. There were very few skilled workers. Most of the people there were farmers and money came from planting crops like cotton, rice, sugar cane and tobacco. It was the slaves who did most of the work on the plantations.
However aside from that, the greatest significant difference leading up to the Civil war was:
“The North favored a protectionist tariff on foreign goods, while the South did not.”