Psychoactive drugs are a class of chemical substances that act on the central nervous system and can alter behavior and cognition. All psychoactive drugs are highly fat-soluble and thus cross the blood-brain barrier readily. Psychoactive drugs alter synaptic transmission by altering neurotransmitter amounts and availability or by affecting receptor activity. In addition to the drug's primary effects on behaviors such as arousal, thought processes, mood, perception, and consciousness, psychoactive drugs can produce a variety of nonbehavioral effects that may more directly affect health and, in some instances, can lead to death.
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