Answer: "She was venerated by the town for her extensive charity work" and "His mistake had blighted his career in the government forever."
Explanation: In the first sentence, since we know "She" had done extensive charity work, we are looking for a word with a positive meaning, similar to "admire," which is what a town would be expected to do: "venerate." In the second sentence, "his career" is what receives the effect of "his mistake," so we can infer that the mistake has ruined his career, and the word closest in meaning is "blight"; "chasten" is also negative, but you can't chasten abstract objects, only people.
