Given what we know, we can confirm that the difference between DNA and RNA would be the presence of a different nucleic base.
What is a nucleic base?
These are the core components that make up nucleic acids. DNA is made up of adenine, thymine, guanine, and cytosine. Meanwhile, RNA is made up of the same bases except that it lacks thymine, instead, it possesses uracil.
Therefore, we can confirm that the key difference between DNA and RNA would be the presence of a different nucleic base in the form of uracil.
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