Pre- and postsynaptic nerve terminals and neurons are the two locations where opioids operate. Opioid effects post-synaptically are often inhibitory.
How do neurotransmitters respond to opioids?
Opioids reduce pain when they bind to the pain route, but they also generate euphoria and release dopamine when they attach to the reward pathway. Dopamine tells the body's neurons to produce a happy feeling, or "high," by sending messages to the neurons in the brain or nerve cells.
What neurotransmitters do opioids affect?
As previously mentioned, opioids cause a neurotransmitter called dopamine to release excessive amounts, which reduces pain.
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