Junction which brings the plasma membranes of adjacent cells into close proximity, preventing the paracellular passage of most soluble molecules.

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The junction which brings the plasma membranes of adjacent cells into close proximity is called the tight junction.

Tight junctions separate tissue spaces and form a continuous intercellular barrier between epithelial cells necessary to regulate the selective movement of solutes across the epithelium. Tight junctions refer to specialized junctions between two adjacent animal cell membranes, usually leaving no space between them. A gap junction refers to the junction of two adjacent cells consisting of a system of channels spanning the gap of one cell. other allows through. For example, the tight junctions between the epithelial cells lining the bladder prevent urine from leaking into the extracellular space which is present in the plasma membrane.

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