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Neuroticism and the amygdala's EC are related. Neuroticism and the EC from the right amygdala to the right middle frontal cortex were shown to be positively correlated (MFG).

In psychology and development, neuroticism is a wide personality characteristic dimension that reflects how much a person finds the outside world to be upsetting, dangerous, and unsettling. On this personality dimension, each person may be found midway between the two extreme poles of absolute emotional stability and total emotional turmoil. People who are very neurotic often exhibit labile (often shifting) emotions, are tense, worried, and withdrawn. People with low neuroticism tend to be happy, secure, and stable. The latter group reports less psychological and physical issues as well as less stress than do highly neurotic people.

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