t has been observed (using an electron microscope) that when the red blood cells are sickled there are little spikes that puncture the plasma membrane.

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Because of the aberrant hemoglobin, red blood cells become stiff and sticky and resemble the C-shaped "sickle" farm implement. The early death of sickle cells results in a persistent lack of RBC.

What may be inferred by examining blood under a microscope?

By analyzing blood under a microscope, diseases such as bacteria, fungus, and parasites can be found.

What kind of microscope are red blood cells examined under?

The surface morphology of the blood sample can be seen with a scanning electron microscope at increased magnification (SEM). Transmission electron microscopes (TEM) are used to examine blood cells on a cellular level.

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