Respuesta :
Benzaldehyde substrates using the transient directing group strategy. Without installing any auxiliary directing group, Pd(II)-catalyzed C–H arylation, chlorination, bromination, and Ir(III)-catalyzed amidation, could be achieved on benzaldehyde substrates.
The only Pd-catalyzed C-H functionalizations favored by ephemeral directing groups continue to be C-H arylation. Here, we present a broad range of ortho-C(sp2)-H functionalizations of benzaldehyde substrates that were achieved by employing a transient directing group technique. Pd(II)-catalyzed C-H arylation, chlorination, bromination, and Ir(III)-catalyzed amidation could all be accomplished on benzaldehyde substrates without the use of an auxiliary directing group. The potential for metal-catalyzed C-H functionalization of benzaldehydes is greatly increased by the temporary directing groups produced in situ by imine linkage that can override other coordinating functional groups that can direct C-H activation or catalyst poisoning. Numerous uses of this strategy, such as the late-stage diversification of a pharmacological counterpart, show its usefulness. A benzene ring with a formyl substituent makes up the chemical molecule known as benzoaldehyde (C6H5CHO). The simplest aromatic aldehyde is this one.
Learn more about Benzaldehyde here:
https://brainly.com/question/28146845
#SPJ4
