The first radioiodine isotopes to be used to treat thyrotoxicosis were iodine-130 and iodine-131 in 1941, and thyroid cancer was added to their list of uses in 1943.
What is Reactor produced radioiodine?
- Iodine-131, the most frequently prescribed radioiodine isotope for treating thyroid conditions, is a radioactive created in reactors and is widely available in the market. Uranium-235 isotope fission and the so-called (n, ) reaction are its two primary production processes.
- Iodine-131 is a radioisotope that is simple to obtain in pure form as its chain yield is quite high and radioiodine isotopes with masses higher than 131 have a short half-life.
- Contrarily, Technetium-130 undergoes a reaction with (n, ) to produce Technetium-131m and Technetium-131g. Depending on whether a wet chemical separation or a dry distillation process is employed, TeO2 or Te-metal is the target material for irradiation.
- Iodine-131 has a high radiochemical purity and is marketed as a diluted sodium hydroxide solution. When using iodine-131 to identify organic molecules, it may interfere if a certain reducing agent is used to preserve the isotope in the form of iodide in certain solutions.
- Another radioisotope created in reactors is iodine-125, which is formed when Xenon-124 undergoes the (n, ) reaction. High chemical and radiochemical purity iodine-125 is marketed as a diluted sodium hydroxide solution. It contains 4 to 11 GBq/ml of radioactive material.
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