R5-tropic HIV is required for maraviroc to be considered appropriate for use.
Maraviroc is used in conjunction with other medications to treat human immunodeficiency virus infections (HIV). The virus that causes AIDS is known to induce a lack of immune system function (AIDS). Patients who have previously undergone HIV treatment typically receive this medication.
The kind of HIV that attaches to the CD4 cell's CCR5 coreceptor before entering and infecting the host cell. HIV must first bind to a CD4 receptor, then to either the CCR5 or CXCR4 coreceptor, and ultimately fuse its membrane with the membrane of the CD4 cell in order to enter a CD4 cell. During the initial stages of infection.
Hence, maraviroc uses of R5-tropic HIV for mechanism of action.
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