Because ectopic adrenocorticotropic hormone is improperly secreted, small cell lung cancer (SCLC), which arises from neuroendocrine tissue, can lead to paraneoplastic endocrine disorders including Cushing syndrome (ACTH).
In the neuroendocrine cells of your lungs, SCLC begins. These cells behave somewhat similarly to nerve cells. But they are also capable of producing hormones, such as glucocorticoids. You can get Cushing syndrome when a tumour that began in your lungs continuously exposes your body to the hormones it produces.
Usually, a hidden, slowly expanding bronchial carcinoid tumour causes ectopic ACTH output. Conventional imaging techniques, such as computerised tomography (CT) or magnetic resonance imaging, might make it challenging to diagnose these very small tumours (MRI).
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