Respuesta :
The name "endotoxin shock," which is thought to result from the release of a toxin from gram-negative bacteria, provides a therapeutic conundrum for medical professionals.
Inflammation brought on by endotoxin: how?
TLR4 is the receptor that endotoxin uses to trigger an inflammatory response, including rising TNF- levels. Endotoxin activates kupffer cells, the body's first line of defense. In human NASH, there has been noted Kupffer cell activation.
How can septic shock result from endotoxin?
Syndrome of Septic Shock, Endotoxins generated during severe Gram-negative bacterial infections are the main cause of septic shock in humans, which has a startling 30–50% death rate (Danner et al., 1991).
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