Question

if the albino phenotype occurs in 1/10,000 individuals in a population at equilibrium and albinism is caused by an autosomal recessive allele a, calculate the frequency of (a) the recessive mutant allele;

Answer 1

The frequency of the recessive mutants allele is

2pq=2x0.01x0.99=0.0198 of the albinism in population.

Hardy-Weinberg equation is a mathematical version that calculates the frequency of an allele in a population.

p represents the frequency of dominant allele q represents the frequency of recessive allele 2pq represents the frequency of heterozygotes

p^2 2 +2pq+q^2 2 =1

Albino phenotype is recessive and takes place in 1 out of ten thousand individuals. q^2 2 =0.0001 q=0.01

Normal phenotype takes place in dominant homozygous and heterozygous individuals. p^2 2 +2pq=0.9999 p=1-q=1-0.01=0.99

2pq=2x0.01x0.99=0.0198

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