Someone with a chromosomal make-up of xy where the cells have a partial or complete inability to respond to androgens describes an intersex condition known as 5-alpha reductase deficiency (5ARD).
5α-reductase deficiency is a condition that affects prenatal and adolescent. A person with this condition is genetically male, has his one X and one Y chromosome in each cell, and has male testes.
DHT is the most potent androgen hormone and is considered a pure androgen because it cannot be converted to estrogen. It is formed primarily in the peripheral tissues of the body, where it exerts its effects. Testosterone is converted to DHT by the action of the 5-α-reductase enzyme on these target tissues.
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