Question

A 45-year-old man presents to the emergency department with cellulitis of his left leg. He is being treated with vancomycin. Ten minutes after the infusion is initiated, he complains of intense pruritus and lightheadedness. Erythema is noted on his face and neck. Which of the following is the next best step in the management of this patient?
A Administer intramuscular epinephrine and decrease the rate of the infusion
B Administer intramuscular epinephrine and suspend the infusion
C Administer intravenous diphenhydramine and decrease the rate of the infusion
D Administer intravenous diphenhydramine and suspend the infusion

Answer 1

Diphenhydramine injection is available as a solution (liquid) that may be administered intravenously or intramuscularly (into a vein). Your illness and how you react to therapy will determine your dose regimen.

Although an IV push of diphenhydramine would have a rapid start, it might also result in adverse effects, intravenously necessitating more nursing time to monitor patients. Diphenhydramine can be safely delivered to patients when given as diluted IV admixtures during intravenously an IV infusion.

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