Question

After malaria is cured, the frequency of the HbS allele should decrease in regions with lots of mosquitoes because: A. People will no longer die from sickle-cell disease in these regions. B. Having one copy of the HbS allele will no longer be advantageous in these regions. C. Natural selection will no longer act on the HbS allele at all in these regions D. All alleles associated with genetic disease eventually disappear

Answer 1

The correct answer is option b: HbS allele has a selective advantage of protection against malaria.

Sickle cell anemia is a genetic disorder characterised by sickle-shaped red blood cells caused by a mutation in the beta chain of hemoglobin. The researchers discovered an increased frequency of the HbS allele in malaria-prone areas. This is because people with the sickle cell allele have a selective advantage in areas where malaria is prevalent. As malaria becomes less lethal, the selection for a genetic mutation that protects against the disease declines. As a result, the prevalence of the sickle cell allele is expected to fall.

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