Organ injury. sickle-shaped red blood cells as a result of mutated hemoglobin proteins. Sickle cells that restrict blood flow deplete organs of both oxygen and blood. In sickle cell anemia, blood oxygen levels are also abnormally low. This deficiency in oxygen-rich blood can be lethal and harm nerves and organs including the kidneys, liver, and spleen.
The most frequent cause of Sickled cells complications and the main reason patients with Sickled cells visit the ER or hospital is pain. Sickled cells can become caught and impede blood flow throughout the body when moving via tiny blood veins, which hurts.
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