PDC is a multienzyme complex which catalyzes the conversion of pyruvate from glycolysis into acetyl-CoA.
Pyruvate dehydrogenase (E1), dihydrolipoamide transacetylase (E2), and dihydrolipoamide dehydrogenase make up the 9.5 MDa complex known as PDH (E3). The E2/E3 protein kinase is an extra structural component required to promote the connections between both the E2 & E3 subunits. The multienzyme PDC contains the pyruvate dehydrogenase (PDH) enzyme, which is sometimes described to as a "gatekeeper" in the oxidation of carbohydrates. PDH catalyzes the biologically irreparable decarboxylation of pyruvate to acetyl-CoA. Three distinct enzymes—pyruvate dehydrogenase, dihydrolipoyl transacetylase, & dihydrolipoyl dehydrogenase—perform the total process. They combine to create a tight multienzyme complex that is simple to separate as such by mitochondrial extraction.
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